SIKIK FUNDAMENTALS EXPLAINED

The operate of SIK1 in tumorigenesis. SIK1 is actually a tumor suppressor gene, which plays a significant regulatory job in GNAS, KRAS mutation and LKB1 deletion mediated tumors. SIK1 inhibits CREB mediated transcription and affects cancer mobile proliferation, metabolic reprogramming and inflammatory microenvironment. SIK1 could also advertise can